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Curr Opin Rheumatol. 2002 Jul;14(4):399-403.

Host-pathogen interactions and the pathogenesis of murine Lyme disease.

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Division of Cell Biology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132-2501, USA.


Lyme disease results from persistent infection with the spirochete Borrelia burgdorferi. A combination of bacterial factors and host factors contributes to the development of inflammatory disease. Studies from the past year have provided insight into both sides of this host-pathogen interplay. We now have a better appreciation of the bacterial genes and products that are involved in pathology and the components of the host response that participate in disease development.

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