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Infect Immun. 2002 Aug;70(8):4682-6.

Colony-stimulating factor 1-dependent cells protect against systemic infection with Listeria monocytogenes but facilitate neuroinvasion.

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1
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Abstract

By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor 1 and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.

PMID:
12117983
PMCID:
PMC128173
[Indexed for MEDLINE]
Free PMC Article
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