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Pharmazie. 2002 Jun;57(6):358-61.

Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei.

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1
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon. bnyasse@uycdc.uninet.cm

Abstract

Phytochemical study of the stem bark of Enantia chlorantha resulted in the isolation of two protoberberines 1 and 2. These alkaloids as well as commercially available berberine were modified chemically and tested in vitro against Typanosoma brucei proliferation as well as on three targeted glycolytic enzymes. The inhibitory activities observed were in the range of 20 microM (ED50 values).

PMID:
12116870
[Indexed for MEDLINE]
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