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Lancet. 2002 Jul 6;360(9326):58-60.

Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia.

Author information

1
United States Naval Medical Research Unit #2, Jakarta, Indonesia. maguirejd@namru2.med.navy.mil

Abstract

Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (> or = 100 microg/L) on day 8 in both cases of persistent parasitaemia. These findings suggest that clinical resistance to chloroquine by P malariae occurs in the Indonesian archipelago of southeast Asia.

PMID:
12114045
DOI:
10.1016/S0140-6736(02)09336-4
[Indexed for MEDLINE]

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