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Bioorg Med Chem Lett. 2002 Aug 5;12(15):1993-6.

Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy.

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1
Department of Chemistry, University of Illinois at Chicago, 60607, USA. arunghos@uic.edu

Abstract

A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease.

PMID:
12113826
[Indexed for MEDLINE]
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