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Cancer Immunol Immunother. 2002 Aug;51(6):293-8. Epub 2002 Apr 24.

Immature myeloid cells and cancer-associated immune suppression.

Author information

1
H. Lee Moffitt Cancer Center, University of South Florida, MRC-2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Abstract

Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.

PMID:
12111117
DOI:
10.1007/s00262-002-0280-8
[Indexed for MEDLINE]

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