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Nature. 2002 Jul 11;418(6894):244-51.

RNA interference.

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1
Cold Spring Harbour Laboratory, New York 11724, USA. hannon@cshl.org

Abstract

A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

PMID:
12110901
DOI:
10.1038/418244a
[Indexed for MEDLINE]
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