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Nature. 2002 Jul 11;418(6894):222-8.

The chemical repertoire of natural ribozymes.

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1
Department of Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA. doudna@uclink.berkeley.edu

Abstract

Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity--they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.

PMID:
12110898
DOI:
10.1038/418222a
[Indexed for MEDLINE]
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