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Behav Brain Res. 2002 Jul 18;133(2):159-64.

Time-dependent involvement of PKA/PKC in contextual memory consolidation.

Author information

1
Department of Psychology, Cognitive Neurobiology Institute, University of Utah, Salt Lake City 84112, USA. cogneuro_institute@hotmail.com

Abstract

Rats were implanted bilaterally with cannulae into the dorsal hippocampus and trained in a Pavlovian fear-conditioning paradigm. Four groups of rats were infused intra-cranially with 1-(5'-isoquinolinesulfonyl)-2-methylpiperazine (H7-dihydrochloride), a potent inhibitor of both protein kinase C (PKC) and cAMP-dependent protein kinase (PKA), at different time intervals in order to examine their involvement in the acquisition and consolidation of contextual fear memory. We demonstrate a significant consolidation deficit of long-term contextual fear-conditioning memory that is maximal when PKA and PKC are inhibited at 90 min post-training. These results suggest the existence of a critical time window, during which these enzymes must be activated for the consolidation of long-term memories.

PMID:
12110449
[Indexed for MEDLINE]

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