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Trends Microbiol. 2002 Jul;10(7):324-31.

Picornavirus-receptor interactions.

Author information

1
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA. mgr@indiana.bio.purdue.edu

Abstract

Many picornaviruses use cell-surface molecules belonging to the immunoglobulin superfamily (IgSF) as their cellular receptors. These molecules usually consist of tandem repeats of between two and five Ig-like domains whose amino-terminal domains (D1) interact with invading viruses, with their carboxy-terminal sections comprising a transmembrane and a short cytoplasmic region. Most rhino- and enteroviruses, belonging to the Picornavirus family, use a canyon-like feature on their surface to attach to cellular receptors. Binding into the canyon destabilizes the virus and thus initiates the uncoating process. By contrast, non-IgSF molecules, when used by picornaviruses as receptors, bind outside the canyon and do not cause viral instability.

PMID:
12110211
[Indexed for MEDLINE]

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