Format

Send to

Choose Destination
See comment in PubMed Commons below
Arthritis Res. 2002;4 Suppl 3:S109-16. Epub 2002 May 9.

Endothelial activation: intracellular signaling pathways.

Author information

1
Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06510, USA. jordan.pober@yale.edu

Abstract

Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.

PMID:
12110129
PMCID:
PMC3240152
DOI:
10.1186/ar576
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center