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Biomaterials. 2002 Sep;23(17):3673-80.

A new method to produce macropores in calcium phosphate cements.

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Facultad de Farmacia, Departamento de Química Inorgánica y Bioinorgánica, Madrid, Spain.


A new way to create macropores in calcium phosphate cements has been developed. The method consists in adding NaHCO3 to the starting cement powder (Biocement D) and using two different liquids: first a basic liquid to form the paste and later an acid liquid to obtain CO2 bubbles. Mercury intrusion measurements showed a dramatic increase both in macropores with an average size of 100 m and in the total porosity (even higher than 50% with respect to the Biocement D). This method does not change in any significant way the final reaction products of the starting material after being soaked 3 days in Ringer solution. Only, due to the increase of the porosity. the compressive strength of the porous cement decreases significantly.

[Indexed for MEDLINE]

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