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Microbes Infect. 2002 Jul;4(9):999-1006.

VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.

Author information

1
Laboratory of Cellular Immunology, Free University of Brussels/Flemish Interuniversity, Institute for Biotechnology, Paardenstraat 65, Sint Genesius Rode, Belgium. stemagez@vub.ac.be

Abstract

African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology.

PMID:
12106794
[Indexed for MEDLINE]

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