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Microbes Infect. 2002 Jul;4(9):945-53.

Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.

Author information

1
Institut de Pharmacologie et de Biologie Structurale, CNRS, 205 route de Narbonne, Toulouse, France.

Abstract

The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis.

PMID:
12106787
DOI:
10.1016/s1286-4579(02)01621-0
[Indexed for MEDLINE]

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