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Arthritis Res. 2002;4(4):237-40. Epub 2002 Feb 1.

The role of statins as potential targets for bone formation.

Author information

1
OsteoScreen, San Antonio, Texas 78229, USA. garrett@osteoscreen.com

Abstract

Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene expression of bone morphogenetic protein-2, which is an autocrine-paracrine factor for osteoblast differentiation. The findings that statins increase bone formation and bone mass in rodents suggest a potential new action for these compounds, which may be beneficial in patients with established osteoporosis where marked bone loss has occurred. Recent clinical data suggest that they may reduce the risk of fracture in patients taking these drugs.

PMID:
12106493
PMCID:
PMC128929
DOI:
10.1186/ar413
[Indexed for MEDLINE]
Free PMC Article

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