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Sphingosine kinases: a novel family of lipid kinases.

Author information

1
Department of Biochemistry, Virginia Commonwealth University, Richmond 23298, USA.

Abstract

Sphingosine kinase (SPHK) catalyzes the formation of sphingosine-1-phosphate (S11). S1P plays an important role in regulation of a variety of biological processes through intracellular and extracellular actions. S1P has recently been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors. To date, seven cloned SPHKs have been reported with confirmed SPHK activity, including human, mouse, yeast, and plant. A computer search of various databases suggests that a new SPHK family is emerging. The cloning and manipulation of SPHK genes will no doubt provide us with important information about the functions of S1P in a wide range of organisms.

PMID:
12102559
DOI:
10.1016/s0079-6603(02)71049-0
[Indexed for MEDLINE]

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