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Curr Opin Genet Dev. 2002 Aug;12(4):441-6.

Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators.

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1
Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia.

Abstract

SOX transcription factors perform a remarkable variety of important roles in vertebrate development, either activating or repressing specific target genes through interaction with different partner proteins. Surprisingly, these interactions are often mediated by the conserved, DNA-binding HMG domain, raising questions as to how each factor's specificity is generated. We propose a model whereby non-HMG domains may influence partner protein selection and/or binding stability.

PMID:
12100890
[Indexed for MEDLINE]
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