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Acta Neurol Scand. 2002 Aug;106(2):63-83.

Human herpes virus 6 and multiple sclerosis.

Author information

1
Department of Nurology, McGill University, Montereal, Quebec, Canada. fmoore1@po-box.mcgill.ca

Abstract

OBJECTIVES:

To systematically review the published evidence for a relationship between human herpes virus 6 (HHV-6) and multiple sclerosis (MS).

MATERIALS AND METHODS:

The medical literature was searched using MEDLINE and the Cochrane database. Retrieved studies are presented according to the experimental technique(s) used. The studies are rated for quality using a priori defined criteria.

RESULTS:

Twenty-eight studies were retrieved. A total of 12 different experimental techniques were used. Four of these techniques provided evidence for a relationship between HHV-6 and MS, but none were able to show a causative relationship.

CONCLUSIONS:

The available literature provides some support for a relationship between HHV-6 and MS. The limitations of the available studies and directions for future research are discussed.

[Indexed for MEDLINE]

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