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Br J Dermatol. 2002 Jul;147(1):139-43.

Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours.

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  • 1Department of Dermatology, School of Medicine, Chungnam National University, 640 Taesa-dong, Chung-gu, Taejon, 301-040 Korea.


We report multiple occurrences of various kinds of tumours that originate from hair follicles in a patient diagnosed with KID (keratitis, ichthyosis, deafness) syndrome. These tumours are diagnosed as: (i) trichilemmal cysts in early lesions; (ii) proliferating trichilemmal tumours in moderate duration lesions; and (iii) malignant proliferating trichilemmal tumours in advanced lesions that are thought to progress from benign trichilemmal lesions. This three-step process raises the hypothesis of a multihit model that could account for the frequent development of tumours in KID patients.

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