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Ann N Y Acad Sci. 2002 Jun;963:140-3.

Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells.

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Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and Robert Bosch Hospital, Department of Clinical Chemistry, 70376 Stuttgart, Germany.


To obtain more information about the interactions between antiestrogens and transforming growth factor beta (TGF-beta) signaling, we analyzed the influence of different types of antiestrogens on the expression of TGF-beta receptors I (TbetaRI) and II (TbetaRII). Our results show that antiestrogens selectively induce TbetaRII but not TbetaRI mRNA.

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