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Nat Rev Immunol. 2002 Jul;2(7):465-75.

BAFF: a fundamental survival factor for B cells.

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1
Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia. f.mackay@garvan.unsw.edu.au

Abstract

B-cell-activating factor of the tumour-necrosis-factor family (BAFF) enhances B-cell survival--a function that is indispensable for B-cell maturation--and has a role in enhancing immune responses. Moreover, the overexpression of BAFF results in severe autoimmune disorders in mice, and elevated serum levels of BAFF occur in some patients who have autoimmune diseases. The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease.

PMID:
12094221
DOI:
10.1038/nri844
[Indexed for MEDLINE]
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