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Nat Rev Mol Cell Biol. 2002 Jul;3(7):531-7.

Opinion: Building epithelial architecture: insights from three-dimensional culture models.

Author information

1
Department of Anatomy, and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA.

Abstract

How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.

PMID:
12094219
DOI:
10.1038/nrm859
[Indexed for MEDLINE]

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