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Nat Rev Immunol. 2002 Jun;2(6):439-46. doi: 10.1038/nri823.

Activation rules: the two-signal theories of immune activation.

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  • 1Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia. A.Baxter@centenary.usyd.edu.au

Abstract

Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental observations and theoretical concerns that have helped to forge the most influential variants of the theory. We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future.

PMID:
12093010
DOI:
10.1038/nri823
[PubMed - indexed for MEDLINE]
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