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J Pediatr. 2002 Jul;141(1):45-50.

Prediction of outcome after hypoxic-ischemic encephalopathy: a prospective clinical and electrophysiologic study.

Author information

1
Pediatric Intensive Care Unit, the Department of Neurophysiology, University Hospital of Lille, France.

Abstract

OBJECTIVES:

To evaluate and compare the predictive value of history, clinical examination, and biologic and electrophysiologic data regarding the prognosis of children with acute hypoxic-ischemic encephalopathy (HIE).

STUDY DESIGN:

Prospective cohort of 57 consecutive children who were mechanically ventilated for HIE throughout a 3-year period in a tertiary pediatric intensive care unit at a university hospital in France.

RESULTS:

At 24 hours after admission, 12 patients had died, 3 were awake and 42 showed impaired consciousness or were in a coma, of whom 38% had a favorable outcome. In this group, an initial cardiopulmonary resuscitation duration longer than 10 minutes and a Glasgow Coma Scale <5 at 24 hours after admission were associated with an unfavorable outcome (positive predictive value [PPV] 91%, 100%; sensitivity 50%, 54%). A discontinuous electroencephalogram (EEG), the presence of spikes or epileptiform discharges were associated with an unfavorable outcome (PPV 100% for the 2 criteria; sensitivity 27%, 54%). The bilateral absence of the N20 wave on short-latency sensory evoked potentials (SEPs) had a PPV for unfavorable outcome of 100% (sensitivity 63%).

CONCLUSIONS:

The clinical assessment combined with EEG and SEPs allow an early prediction of the prognosis of children with HIE.

PMID:
12091850
DOI:
10.1067/mpd.2002.125005
[Indexed for MEDLINE]

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