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Clin Neurophysiol. 2002 Jul;113(7):1092-8.

Post-exercise facilitation and depression of M wave and motor evoked potentials in healthy subjects.

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Department of Neurology, Aarhus University Hospital, Denmark.



To characterize so-called central fatigue, the effect of various levels of exercise on central and peripheral motor potentials were compared.


Thirteen healthy subjects performed 4 levels of exercise following isometric dorsiflexion of the foot. Post-exercise recordings from the anterior tibial muscle of motor evoked potentials (MEP) evoked by transcranial magnetic stimulation (TMS) and M wave evoked by electrical stimulation of the peroneal nerve were performed.


After 5 s the post-exercise MEP amplitude increased. The increase was related to the degree of work performed. Subsequently, there was a gradually decrease of amplitude reaching statistical significance after 15 min. The area of the M wave increased significantly after 10 s and returned to baseline after 2-3 min.


Facilitation and depression of MEP after fatiguing exercise is at least partly a peripheral phenomenon dependent on the level of exercise performed.

[Indexed for MEDLINE]

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