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Curr Opin Immunol. 2002 Aug;14(4):517-21.

Humoral immunity and long-lived plasma cells.

Author information

1
Department for Humoral Immunology, German Arthritis Research Centre, Berlin, Schumannstrasse 21/22, Berlin, Germany. manz@drfz.de

Abstract

A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.

PMID:
12088688
DOI:
10.1016/s0952-7915(02)00356-4
[Indexed for MEDLINE]

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