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Curr Opin Immunol. 2002 Aug;14(4):503-8.

T cell immunity in lymphoid and non-lymphoid tissues.

Author information

1
Division of Immunology, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319, USA. llefranc@neuron.uchc.edu

Abstract

Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.

PMID:
12088686
DOI:
10.1016/s0952-7915(02)00360-6
[Indexed for MEDLINE]

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