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Trends Neurosci. 2002 Jun;25(6):284-6.

Jekyll-Hyde neurotrophins: the story of proNGF.

Author information

1
Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden. carlos.ibanez@neuro.ki.se [corrected]

Erratum in

  • Trends Neurosci 2002 Jul;25(7):378.

Abstract

Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide is both a preferential high-affinity ligand for p75(NTR) (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.

PMID:
12086739
DOI:
10.1016/s0166-2236(02)02169-0
[Indexed for MEDLINE]

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