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Free Radic Biol Med. 2002 Jul 1;33(1):142-8.

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.

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Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd., Sakado-shi, Saitama, Japan.


We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

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