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Cell. 2002 May 17;109(4):413-6.

Clathrin adaptors really adapt.

Author information

1
Department of Cell Biology, Harvard Medical School and The Center for Blood Research, Boston, MA 02115, USA. kirchhausen@xta1200.harvard.edu

Abstract

The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with the membrane and cytosolic tails of cargo proteins.

PMID:
12086597
DOI:
10.1016/s0092-8674(02)00751-1
[Indexed for MEDLINE]
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