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Cell. 2002 May 17;109(4):409-12.

Sex, AGility, and the regulation of alternative splicing.

Author information

1
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington 06030, USA. graveley@neuron.uchc.edu

Abstract

Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.

PMID:
12086596
DOI:
10.1016/s0092-8674(02)00750-x
[Indexed for MEDLINE]
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