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Cell. 2002 May 17;109(4):409-12.

Sex, AGility, and the regulation of alternative splicing.

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Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington 06030, USA.


Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.

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