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Scand J Prim Health Care. 2002 Mar;20(1):50-6.

Influence of mild infections on iron status parameters in women of reproductive age.

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1
Department of Public Health and Primary Health Care, University of Bergen, Norway.

Abstract

OBJECTIVE:

To investigate the effects of mild infections on iron status parameters.

DESIGN:

A prospective observational study.

SETTING:

A population of female nurse students in Norway.

SUBJECTS:

33 women with self-reported episodes of infection and 33 women without infections but with comparable s-ferritin at baseline.

MAIN OUTCOME MEASURES:

Change from baseline in haemoglobin, s-iron, TIBC, transferrin saturation, s-ferritin, e-protoporphyrin and s-transferrin receptor on days 3, 7, 14, 21, 28 and 56 after onset of illness, compared to changes in non-infected subjects tested in parallel.

RESULTS:

In febrile illness, such as influenza, there was a significant rise in s-ferritin that could take more than a month to normalise. S-ferritin increased significantly when CRP rose above 20 mg/L, but a normal CRP could not preclude falsely high s-ferritin values due to infection. S-iron and transferrin saturation fell below normal range in a substantial proportion of cases in the symptomatic stage, even in infections without a febrile response, such as the common cold, but was normalised within a week after onset of infection.

CONCLUSION:

For more than a month after febrile illness such as influenza, s-ferritin is not a reliable measure for ruling out iron deficiency in women of reproductive age.

PMID:
12086285
DOI:
10.1080/028134302317282752
[Indexed for MEDLINE]

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