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Br J Cancer. 2002 May 20;86(10):1529-33.

Generation of dendritic cell-based vaccines for cancer therapy.

Author information

  • 1Klinik und Poliklinik für Dermatologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Germany.

Abstract

Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.

PMID:
12085199
PMCID:
PMC2746586
DOI:
10.1038/sj.bjc.6600316
[PubMed - indexed for MEDLINE]
Free PMC Article
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