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Neurology. 2002 Jun 25;58(12):1852-5.

Reduced cortical gray matter in narcolepsy: preliminary findings with voxel-based morphometry.

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Research Group Neurophysiology of Sleep, Max Planck Institute of Psychiatry, Munich, Germany.


There is a selective loss of hypocretin/orexin-containing hypothalamic neurons in patients with narcolepsy. The authors compared MRI-derived gray matter maps of 12 patients with narcolepsy with matched controls using voxel-based morphometry to ascertain whether there are other structural brain abnormalities. Patients with narcolepsy showed bilateral cortical gray matter reductions predominantly in inferior temporal and inferior frontal brain regions. Relative global gray matter loss was independent of disease duration or medication history. No significant subcortical gray matter alterations were noted.

[Indexed for MEDLINE]

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