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Neoplasia. 2002 Jul-Aug;4(4):312-23.

Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector.

Author information

1
Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurologic Disorders and Stroke/NIH, 10 Center Drive, Bethesda, MD, USA.

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of transformed cell lines, but generally spares most normal cells. Transduction by an adenoviral vector expressing human TRAIL cDNA (Ad.TRAIL-GFP) resulted in both direct tumor cell killing as well as a potent bystander effect through presentation of TRAIL by transduced normal cells. Administration of Ad.TRAIL-GFP significantly prolonged survival of mice harboring either intracerebral glioblastomas or breast carcinoma-induced peritoneal carcinomatosis. Additionally, TRAIL induced prolonged transgene expression in normal tissue, presumably as a result of diminished immune-mediated destruction of vector-transduced cells. Taken together, these data suggest that vector-mediated transduction of TRAIL may represent an effective strategy for cancer gene therapy.

PMID:
12082547
PMCID:
PMC1531709
DOI:
10.1038/sj.neo.7900245
[Indexed for MEDLINE]
Free PMC Article

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