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J Perinatol. 2002 Jul-Aug;22(5):367-9.

Continuous blood gas monitoring using an in-dwelling optode method: clinical evaluation of the Neotrend sensor using a luer stub adaptor to access the umbilical artery catheter.

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Department of Neonatology, Children's National Medical Center and The George Washington University School of Medicine, Washington, DC 20010, USA.



Arterial blood gases are essential in the management of critically ill neonates. A new technology using the Neotrend system (Diametrics Medical) allows for continuous measurement of pH, PaCO(2), and PaO(2), and calculates oxygen saturation, bicarbonate, and base excess.


To evaluate and compare the results of continuous blood gas measurement using the Neotrend system with a standard system of blood gas analysis in our intensive care unit.


Prospective, controlled, interventional study.


The neonatal intensive care unit of a tertiary referral center.


Neonates with respiratory distress who required respiratory support and frequent arterial blood gas sampling and had a UAC.


To enable Neotrend sensor access to an existing Argyle umbilical artery catheter (UAC) the catheter was cut at the 25-cm mark and connected to an 18-gauge blunt needle luer stub adaptor (Vygon 95440). The study began with the insertion of the Neotrend sensor. Subjects remained on the study until the UAC was discontinued and/or frequent blood gases were no longer needed. The blood gas results from the Neotrend system were not used in clinical management of the patient. BLOOD GAS MEASUREMENT: During the study period, with each blood sample drawn for laboratory analysis, a printout from the Neotrend monitor was recorded for comparison.


A total of 217 pairs of blood gas samples were collected from seven neonates. The mean bias/precision for pH was 0.01/0.04; for PaO(2) 0.72/18.5 mm Hg; and for PaCO(2) 3.96/2.63 mm Hg. The correlation (r value) between the sensor reading and the blood gases were 0.85 for pH, 0.96 for PaO(2), and 0.92 for PaCO(2).


The blood gases compared in the two methods had a strong correlation for pH, PaCO(2), PaO(2), and oxygen saturation. Although the bicarbonate and base excess values showed suboptimal statistical correlation, the difference was not clinically relevant. Results of this study indicate that this technology provides an accurate means of monitoring continuous blood gas parameters in neonatal patients. It also allows reduced healthcare provider exposure to blood and decreased patient iatrogenic blood loss.

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