Format

Send to

Choose Destination
Science. 2002 Jun 21;296(5576):2178-80.

Intercellular communication in the mammalian ovary: oocytes carry the conversation.

Author information

1
Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA. mmatzuk@bcm.tmc.edu

Abstract

The production of functional female gametes is essential for the propagation of all vertebrate species. The growth of oocytes within ovarian follicles and their development to mature eggs have fascinated biologists for centuries, and scientists have long realized the importance of the ovarian follicle's somatic cells in nurturing oogenesis and delivering the oocyte to the oviduct by ovulation. Recent studies have revealed key roles of the oocyte in folliculogenesis and established that bidirectional communication between the oocyte and companion somatic cells is essential for development of an egg competent to undergo fertilization and embryogenesis. The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action.

PMID:
12077402
DOI:
10.1126/science.1071965
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center