Format

Send to

Choose Destination
Pharmacol Biochem Behav. 2002 Aug;73(1):159-66.

Stress and nerve growth factor: findings in animal models and humans.

Author information

1
Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy. aloe@in.rm.cnr.it

Abstract

Stress is elicited by environmental, social or pathological conditions occurring during the life of animals and humans that determine changes in the nervous, endocrine and immune systems. In the present review, we present data supporting the hypothesis that stress-related events both in animal models and humans are characterized by modifications of endogenous nerve growth factor (NGF) synthesis and/or utilization. Stress inducing alteration in NGF synthesis and/or utilization appears to be more severe during neurogenesis and in early postnatal life. However, NGF endogenously released during stress may promote remodeling of damaged tissues following acute and/or chronic stressful events.

PMID:
12076735
DOI:
10.1016/s0091-3057(02)00757-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center