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Trends Biochem Sci. 2002 May;27(5):219-21.

ML -- a conserved domain involved in innate immunity and lipid metabolism.

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Department of Pathology and Comprehensive Cancer, University of Michigan Medical School, Ann Arbor, MI 48109, USA.


ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.

[Indexed for MEDLINE]

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