Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 2002 Jun 20;417(6891):811-2.

Evolutionary biology: hedgehog crosses the snail's midline.

Author information

1
Department of Developmental Biology, Utrecht University, The Netherlands. alexanderj@nederbragt.net

Abstract

According to the dorsoventral axis-inversion theory, protostomes (such as insects, snails and worms) are organized upside-down by comparison with deuterostomes (vertebrates), in which case their respective ventrally (belly-side) and dorsally (back-side) located nervous systems, as well as their midline regions, should all be derived from a common ancestor. Here we provide experimental evidence for such homology by showing that an orthologue of hedgehog, an important gene in midline patterning in vertebrates, is expressed along the belly of the larva of the limpet Patella vulgata. This finding supports the existence of a similar mechanism for the development of the midline of the nervous system in protostomes and deuterostomes.

PMID:
12075342
DOI:
10.1038/417811b
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center