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Trends Cell Biol. 2002 Jun;12(6):254-7.

MAPK signaling specificity: it takes two to tango.

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Samuel Lunenfeld Research Institute, Room 1080, Mt Sinai Hospital, Toronto, Canada.


A surprisingly limited repertoire of core signaling pathways generates an enormous diversity of responses, often in a cell type-specific manner. Even within one cell, a single pathway might yield two different responses depending on the input signal. In budding yeast, a mitogen-activated protein kinase (MAPK) module seems to transmit both mating pheromone and invasive growth signals in the same yeast cell. We discuss recent insights into mechanisms of differential MAPK activation in this system.

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