Send to

Choose Destination
Cancer J. 2002 May-Jun;8(3):222-33.

The Ki-67 index and survival in non-small cell lung cancer: a review and relevance to positron emission tomography.

Author information

Department of Radiology, University of Washington Medical Center, Seattle 98195, USA.



We reviewed the current literature to discover the range of studies covering tissue-based and noninvasive methods for determining tumor stage and the prognostic value of staging in non-small cell lung cancer.


Despite refinements in staging of non-small cell lung cancer, each stage remains heterogeneous because each stage contains patients who are at higher risk for recurrence than other patients within the same stage. Tissue-based and noninvasive methods have been investigated to complement tumor stage in assessing non-small cell lung cancer prognosis. The prognostic significance of tumor proliferation assessed by Ki-67 protein expression has been demonstrated in non-small cell lung cancer.


Recent positron emission tomography studies have also shown both prognostic value in non-small cell lung cancer uptake of [F-18] fluorodeoxyglucose (FDG) and correlation between non-small cell lung cancer FDG uptake and tumor proliferation.


We reviewed the prognostic significance of Ki-67 expression in non-small cell lung cancer and related it to positron emission tomography.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center