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Appl Microbiol Biotechnol. 2002 Jun;59(1):9-14. Epub 2002 Apr 16.

Biochemistry and molecular genetics of poly-gamma-glutamate synthesis.

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1
Department of Bioresources Science, Kochi University, Nankoku, Kochi, 783-8502, Japan. ashiuchi@cc.kochi-u.ac.jp

Abstract

Current research into poly-gamma-glutamate (PGA) and its biosynthesis is reviewed. In PGA-producing Bacillus subtilis, glutamate racemase supplies abundant DL-glutamate, the substrate for PGA synthesis. The pgsBCA genes of PGA-producing B. subtilis, which encode the membrane-associated PGA synthetase complex PgsBCA, were characterized and the enzyme complex was suggested to be an atypical amide ligase based on its structure and function. A novel reaction mechanism of PGA synthesis is proposed.

PMID:
12073126
DOI:
10.1007/s00253-002-0984-x
[Indexed for MEDLINE]
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