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J Pediatr. 2002 Jun;140(6):707-12.

Prediction of outcome based on clinical seizure type in newborn infants.

Author information

1
Division of Neurology, and the Department of Research, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA.

Erratum in

  • J Pediatr 2002 Sep;141(3):452.

Abstract

OBJECTIVE:

To determine whether the clinical features of neonatal seizures are of value in predicting outcome.

STUDY DESIGN:

Demographic features, clinical seizure types, etiologic factors, and laboratory findings of all 77 patients with seizures admitted to our neonatal intensive care unit over a consecutive 7-year period were extracted from the medical records.

RESULTS:

Twenty-three (30%) died; 59% of the survivors had abnormal neurologic examinations, 40% were mentally retarded, 43% had cerebral palsy, and 21% were epileptic at mean follow-up of 3.5 years. Compared with patients with other seizure types, those with subtle and generalized tonic seizures had a significantly higher prevalence of epilepsy (P =.04 and P =.01 respectively); mental retardation (P =.02; P =.007), and cerebral palsy (P =.03; P =.002). Subtle seizures were, in addition, more likely to be associated with abnormalities on the neurologic examination at follow-up (P =.03). Similar outcome comparisons for those with focal and multifocal clonic, focal tonic, and multifocal myoclonic seizures revealed no significant differences. However, patients with >or=2 seizure types were significantly more likely to have epilepsy (P =.02), mental retardation (P =.001), cerebral palsy (P =.001), and abnormal examinations (P =.05).

CONCLUSIONS:

Clinical semiology is predictive of outcome in neonates with seizures and suggests the presence of unique pathophysiologic processes for different seizure types.

PMID:
12072874
DOI:
10.1067/mpd.2002.124773
[Indexed for MEDLINE]

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