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Endocrinology. 2002 Jul;143(7):2461-5.

Minireview: nuclear receptor coactivators--an update.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

Nuclear receptors (NRs) regulate the expression of target genes in response to activation by steroid hormones and other ligands, as well as a variety of other signaling pathways. NR coactivators are defined as cellular factors recruited by activated NRs that complement their function as mediators of the cellular response to endocrine signals. In this review, we will focus upon advances in our understanding of the function of coactivators as their characterization has progressed from mechanistic studies to an exploration of their biological roles in living animals.

PMID:
12072374
DOI:
10.1210/endo.143.7.8892
[Indexed for MEDLINE]

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