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Life Sci. 2002 Jun 28;71(6):611-22.

Functional characteristics of cysteinyl-leukotriene receptor subtypes.

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Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden.


Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor antagonist BAY u9773. However, the rank order of potency of the cysteinyl-leukotrienes at the CysLT receptors differs between tissues and studies, and a CysLT receptor classification based on agonist selectivity has not been established. In addition, the existence of more than two receptor subtypes for cysteinyl-leukotrienes has been suggested.

[Indexed for MEDLINE]

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