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Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8850-5. Epub 2002 Jun 17.

MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness.

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1
Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

Abstract

Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in gammadelta T cells. This finding suggests that gammadelta T cells function as negative regulators. The regulatory influence of gammadelta T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary gammadelta T cells. These cells express Vgamma4 and depend in their function on the presence of IFN-gamma and MHC class I. Moreover, their effect can be demonstrated in the absence of alphabeta T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.

PMID:
12070351
PMCID:
PMC124387
DOI:
10.1073/pnas.132519299
[Indexed for MEDLINE]
Free PMC Article
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