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Eur J Obstet Gynecol Reprod Biol. 2002 Jul 10;103(2):136-9.

Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section.

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1
Mullikin Medical Center, Artesia, CA 90701, USA.

Abstract

OBJECTIVES:

To investigate the antioxidant defense potential of human neonates according to gestational age and mode of delivery.

STUDY DESIGN:

Four study groups were established, full-term normal spontaneous vaginal delivery (FT-NSVD, n=24), full-term caesarean section (FT-CS, n=19), preterm normal spontaneous vaginal delivery (PT-NSVD, n=15) preterm caesarean section (PT-CS, n=21). The activity of catalase (CAT), glutathion peroxidase (GPX), Cu/Zn superoxide dismutase (Cu/Zn-SOD) were determined from cord blood. Statistical analysis was made by ANOVA.

RESULTS:

CAT activity was significantly higher in full-term than in preterm newborns. In both the categories, neonates born via caesarean section had significantly lower CAT activities. GPX activity was significantly higher in the FT-NSVD group than in any other group. Cu/Zn-SOD activity was significantly higher in full-term neonates than in preterms and no difference was found related to the mode of delivery.

CONCLUSIONS:

Prematurity and caesarean section may cause a deficiency of antioxidant defense in human newborn.

PMID:
12069735
[Indexed for MEDLINE]
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