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J Reprod Med. 2002 May;47(5):363-8.

Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimens.

Author information

1
Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. dgenest@partners.org

Abstract

OBJECTIVE:

To study whether nontriploid partial hydatidiform moles truly exist.

STUDY DESIGN:

We conducted a reevaluation of pathology and ploidy in 19 putative nontriploid partial hydatidiform moles using standardized histologic diagnostic criteria and repeat flow cytometric testing by the Hedley technique.

RESULTS:

On review of the 19 moles, 53% (10/19) were diploid nonpartial moles (initially pathologically misclassified), and 37% (7/19) were triploid partial moles (initial ploidy misclassifications). One additional case (5%) was a diploid early complete mole (initially pathologically misclassified).

CONCLUSION:

Nontriploid partial moles probably do not exist: careful reevaluation of putative specimens will probably uncover pathologic or ploid errors in almost all cases.

PMID:
12068831
[Indexed for MEDLINE]

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